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Where can I buy generic Nucynta / Tapentadol?


Where can I buy generic Nucynta / Tapentadol?

Tapentadol (brand names: Nucynta, Palexia and Tapal) is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI).[1] Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours.[3]

It is similar to Tramadol in its dual mechanism of action; namely, its ability to activate the mu opioid receptor and inhibit the reuptake of norepinephrine.Unlike Tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites. Tapentadol is not a pro-drug and therefor does not rely on metabolism to produce its therapeutic effects; this makes it a useful moderate-potency analgesic option for patients who do not respond adequately to more commonly used opioids due to genetic disposition (poor metabolizers of CYP3A4 and CYP2D6), as well as providing a more consistent dosage-response range among the patient population.

Tapentadol general potency is somewhere between that of tramadol and morphine, with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects. It is generally regarded as a weak-moderate strength opioid.

Medical Use

Tapentadol is used for the treatment of moderate to severe pain for both acute (following injury, surgery, etc.) and chronic musculoskeletal pain. It is also specifically indicated for controlling the pain of diabetic neuropathy when around-the-clock opioid medication is required.

Its general potency is somewhere between that of tramadol and morphine,with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects.

Tapentadol is Pregnancy Category C. There are no adequate and well-controlled studies of Tapentadol in pregnant women, and Tapentadol is not recommended for use in women during and immediately prior to labor and delivery.

There are no adequate and well-controlled studies of Tapentadol in children

 



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