Armodafinil (trade name Nuvigil) is the enantiopure of the wakefulness-promoting agent,or eugeroic, modafinil (Provigil). It consists of just the (−)-(R)-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc.and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Although they have similar half-lives, armodafinil reaches its peak concentration in the blood later after administration than modafinil does, which may make it more effective at improving wakefulness in patients with excessive daytime sleepiness.
Armodafinil is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder. It has been shown to improve vigilance in air traffic controllers.
Armodafinil is approved by the U.S. FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjuvant therapy for obstructive sleep apnea.For narcolepsy and obstructive sleep apnea, Armodafinil is taken as a once daily 150 mg or 250 mg dose in the morning. For shift work sleep disorder, 150 mg of Armodafinil are taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects.
In June, 2010, it was revealed that a phase II study of Armodafinil as an adjunctive therapy in adults with schizophrenia had failed to meet the primary endpoints, and the clinical program was subsequently terminated.However, a study published later that year showed that schizophrenic patients treated with Armodafinil showed fewer of the negative symptoms of schizophrenia.
On March 30, 2010, the FDA declined to approve use of Nuvigil to treat jet lag.
What other drugs will affect Nuvigil?
Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Nuvigil with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with Armodafinil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
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